Fig. 6. TUDC inhibits integrin- and PKA-dependently the GCDC-induced activation of Fyn. Rat livers were perfused with TUDC (20 µmol/l) or GCDC (20 µmol/l) either in absence or presence of (A) GRGDSP (10 µmol/l), GRADSP (10 µmol/l) or H89 (2 µmol/l) or (B) cAMP and/ or H89 as indicated in the perfusion plans. Liver samples were analyzed for phosphorylation of the Src kinases Fyn and Yes by Western blot. Fyn and Yes phosphorylation was quantified by densitometric analysis at t = 90 min (n≥3). * statistically significantly different compared to control. n.s.: not statistically significantly different.